According to the American Cancer Society, inflammatory breast cancer IBC accounts for roughly 1 to 5 percent of all breast cancer diagnoses. Unlike other noninflammatory forms of breast cancer, IBC tends to cause an entirely separate set of symptoms. In some cases, these symptoms can come and go and vary in severity or intensity, depending on how quickly the cancer is growing. IBC symptoms tend to be more prominent and severe than those of noninflammatory breast cancers.
Common symptoms may include:. IBC symptoms are caused by a blockage of the lymphatic system within the breast, which causes pain and swelling. Many of these symptoms develop quickly, usually within a period of 3 to 6 months.
IBC is a fast-growing, aggressive form of breast cancer. Unlike other types of breast cancer, symptoms of this condition are primarily caused by inflammation, which leads to swelling, pain, redness, and other symptoms.
When the symptoms of IBC appear, they may come and go in the beginning. In fact, some of the symptoms mentioned above can appear suddenly and may be mistaken for another condition with similar symptoms, such as an infection or rash.
However, unlike other conditions that resolve over time with treatment, the symptoms of IBC become worse over a period of weeks or months. Although they may vary in intensity, once the cancer has begun to spread, it will continue to cause pain, swelling, and other symptoms in the affected breast. There are a handful of other conditions can share symptoms with inflammatory breast cancer, including the following:. Mastitis is a condition characterized by inflammation and infection of the breast tissue.
Mastitis most often occurs during breastfeeding, when milk ducts become blocked and milk buildup occurs. Many symptoms of mastitis are similar to those of IBC and may include:. Hormonal changes , such as those that occur before menstruation or during pregnancy, are a common cause of breast pain, breast tenderness, and sudden changes in breast size. Unlike IBC, these hormonal symptoms are generally mild and are accompanied by other symptoms, such as:.
Hormonal changes do not tend to cause some of the other symptoms of IBC, like redness or inflammation. Dermatitis is an umbrella term for a handful of inflammatory skin conditions that cause symptoms such as redness, itching, peeling, and more. Atopic dermatitis, contact dermatitis, dyshidrotic dermatitis, and seborrheic dermatitis are the most common types.
Unlike IBC, breast dermatitis tends to affect only the skin of the breast, rather than the underlying breast tissue. Breast injuries that cause trauma to the breast and surrounding areas can cause symptoms that mimic IBC, such as pain, tenderness, and bruising. Learn about treatment for non-metastatic IBC. Lymph node status Most women with IBC have lymph node-positive breast cancer when they are diagnosed [ ].
Learn about clinical trials for IBC. Neoadjuvant before surgery therapy The first treatment for IBC is neoadjuvant chemotherapy , usually with an anthracycline-based chemotherapy and a taxane-based chemotherapy. Surgery and radiation therapy Surgery for IBC is almost always a mastectomy with an axillary dissection. Surgery is followed by radiation therapy.
Almost all women with IBC will need radiation therapy. Breast reconstruction With IBC, breast reconstruction is usually done after radiation therapy is completed, rather than at the same time as the mastectomy. Chemotherapy, hormone therapy and HER2-targeted therapy Treatments after surgery and radiation therapy depend on prior treatment and tumor characteristics [ 7 ]: If chemotherapy was not completed before surgery, the remaining chemotherapy is given after surgery.
Hormone receptor-positive IBC is treated with hormone therapy. Under study Treatments after neoadjuvant therapy for women with IBC who still have cancer in the breast at the time of surgery are under study. Questions for Your Health Care Provider. Will a sentinel node biopsy be done?
How will the status of my lymph nodes affect my treatment plan? Is my tumor hormone receptor-positive or hormone receptor-negative? How does this affect my treatment plan? What are my treatment options? Which treatments do you recommend for me and why?
Should I get chemotherapy or hormone therapy before breast surgery? Will I need more treatment after my surgery? How long do I have to make treatment decisions?
Is there a clinical trial I can join? Can I have a lumpectomy breast conserving surgery plus radiation therapy? If I am having a mastectomy, will I need to have radiation therapy? How will that decision be made?
When will I meet with a radiation oncologist to discuss radiation therapy? Can breast reconstruction be done at the time of the surgery, as well as later? How much later can it be done? Can you refer me to a plastic surgeon? If I choose not to have reconstruction, what types of prostheses are available? Where can I find them? Will my insurance cover the cost? Will you give me a copy of my pathology report and other test results?
What should I consider before treatment begins if I would like to have a child after being treated for breast cancer? What is my follow-up care? Which health care provider is in charge of this care? Who can talk with me about the cost of my treatment including the expenses covered by my insurance and the costs I should expect to pay out-of-pocket?
Will part of my tumor be saved? Where will it be stored? For how long? The latest on newly diagnosed breast cancer Up-to-date information on recurrent breast cancer Specialized treatment information for high risk breast cancer Error Select a topic. Email address. Thank you for subscribing You will receive the first breast cancer email in your inbox shortly, which will include information on treatment, diagnosis, surgery and how breast cancer teams at Mayo Clinic approach personalized care.
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Share on: Facebook Twitter. Show references Breast cancer. National Comprehensive Cancer Network. Accessed Sept. Inflammatory breast cancer. National Cancer Institute. Accessed Oct. Menta A, et al. Inflammatory breast cancer: What to know about this unique, aggressive breast cancer. Surgical Clinics of North America. Palliative care. Invasive breast cancer adult. Mayo Clinic; Bland KI, et al. Elsevier; Mele M, et al. Inflammatory breast cancer: A review from our experience.
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