An FDA public health advisory warns that Chantix can cause severe changes in mood and behavior and can worsen existing mental illnesses, even when patients are already receiving treatment for mental illness. Patients are urged to talk with their doctor about their psychiatric history before taking Chantix, and to report to their doctor any changes in mood and behavior. Chantix also can affect you while driving or using heavy machinery.
The concerns are strong enough that the Federal Aviation Administration has banned pilots and air traffic controllers from taking Chantix. Zyban is an extended-release antidepressant pill that can alleviate nicotine withdrawal symptoms. It works by acting on brain chemicals associated with cravings for nicotine.
Treatment with Zyban typically lasts 7 to 12 weeks. If you don't show significant progress by the seventh week, treatment usually is suspended. The safety and efficacy of Zyban was studied in several trials , using Zyban along with counseling.
In a seven-week study, Zyban was shown to be significantly more effective than placebo. At six months, patients did better at maintaining abstinence after having been treated with Zyban.
In another study, treatment with Zyban was also significantly more effective than placebo, reducing the urge to smoke, and reducing withdrawal symptoms such as irritability, anger, and anxiety. In clinical trials of Chantix, the drug was found to reduce the urge to smoke, reduce withdrawal symptoms, and help patients maintain abstinence.
One study compared Chantix to Zyban to placebo. The study found that both drugs were better than placebo, and concluded that Chantix was more effective than Zyban. The most effective medication should only be determined by your doctor, taking into account your medical condition s , history, and other medications you are taking that could interact with Zyban or Chantix. Zyban generics are typically covered by insurance as well as Medicare Part D.
Chantix is often covered by insurance and Medicare Part D, with variable copays. You can reduce the price of Chantix products with a SingleCare coupon. Zyban is often prescribed along with a nicotine patch also known as nicotine replacement therapy, or NRT , and side effect percentages can be higher when Zyban is used in combination with nicotine.
The most common side effects of Zyban are insomnia, dry mouth, and dizziness. The most common adverse effects of Chantix are nausea, abdominal pain, headache, and insomnia. A medication guide, with detailed information about the medication, will be given to you with a new or refill prescription of Zyban or Chantix. Consult your healthcare provider for a complete list of side effects.
Zyban has a significant amount of drug interactions, detailed in the chart below. Some examples are seizure medications as well as Digoxin , a heart medication. Alcohol should be avoided while on Zyban. Based on the characteristics of the drug, Chantix has no significant drug interactions.
Chantix has not been studied for safety in combination with Zyban. If you get a rash or more serious side effects, contact your doctor or health care professional. How to take Zyban:. It is recommended that you take one mg tablet in the morning for the first three days. On the fourth day, keep taking one tablet in the morning and start taking one tablet in the early evening. If it upsets your stomach, you can take it with food. A study done in Tucson, Arizona found that smokers using Zyban quit smoking more successfully than smokers using a nicotine patch.
Using both Zyban and a nicotine patch helped even more. Why It Is Used Bupropion is approved for use in people who smoke 10 or more cigarettes a day and are at least 18 years old. You should not take bupropion if you: Are already taking other medicines that contain bupropion such as Wellbutrin.
Have seizures or a medical condition that makes you prone to seizures. Are taking a monoamine oxidase inhibitor MAOI. Have an eating disorder. Have an alcohol use problem. Taken as directed, bupropion reduces: Craving. Irritability, restlessness, anxiety. Difficulty concentrating. Feelings of unhappiness or depression. Side Effects Common side effects include: footnote 1 Dry mouth, affecting 1 out of 10 people who use bupropion.
Difficulty sleeping insomnia. If you take a morning and evening dose, taking the evening dose in the afternoon may help with sleep problems.
Take the evening dose at least 8 hours after the morning dose. Less common side effects occurring in less than 10 out of people include: Dizziness.
Upset stomach nausea.
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